| 產(chǎn)品編號 |
bsm-51207M-Cy5.5 |
| 英文名稱 |
Mouse Anti-LOX/Cy5.5 Conjugated antibody
|
| 中文名稱 |
Cy5.5標記的小鼠抗蛋白賴氨酸-6-氧化酶單克隆抗體 |
| 別 名 |
lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領域 |
腫瘤 心血管 細胞生物 免疫學 信號轉(zhuǎn)導 |
| 抗體來源 |
Mouse |
| 克隆類型 |
Monoclonal |
| 克 隆 號 |
4C3 |
| 交叉反應 |
(predicted: Human, Mouse, Rat, Pig, )
|
| 產(chǎn)品應用 |
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
29kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human LOX |
| 亞 型 |
IgG2b |
| 純化方法 |
affinity purified by Protein G |
| 儲 存 液 |
Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Function:
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
Subcellular Location:
Secreted; extracellular space
Tissue Specificity:
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Post-translational modifications:
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Proteolytically activated by BMP1 (By similarity).
Similarity:
Belongs to the lysyl oxidase family.
Database links:
Entrez Gene: 396474 Chicken
Entrez Gene: 4015 Human
Entrez Gene: 16948 Mouse
Entrez Gene: 24914 Rat
Omim: 153455 Human
SwissProt: Q05063 Chicken
SwissProt: P28300 Human
SwissProt: P28301 Mouse
SwissProt: P16636 Rat
Unigene: 102267 Human
Unigene: 172 Mouse
Unigene: 11372 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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