| 產(chǎn)品編號 |
bs-12773R-Cy7 |
| 英文名稱 |
Rabbit Anti-VPS36/Cy7 Conjugated antibody
|
| 中文名稱 |
Cy7標(biāo)記的液泡蛋白分選蛋白36抗體 |
| 別 名 |
C13orf9;
CGI 145;
EAP45;
ELL associated protein of 45 kDa;
ELL-associated protein of 45 kDa;
ESCRT-II complex subunit VPS36;
Vacuolar protein sorting associated protein 36;
Vacuolar protein-sorting-associated protein 36;
Vps36;
VPS36_HUMAN. |
| 規(guī)格價格 |
100ul/2980元
購買 大包裝/詢價 |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
細(xì)胞生物 信號轉(zhuǎn)導(dǎo) 泛素 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human,
(predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
|
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
44kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human VPS36 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Function:
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Subcellular Location:
Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
Similarity:
Belongs to the VPS36 family.
Contains 1 GLUE domain.
Database links:
Entrez Gene: 418883 Chicken
Entrez Gene: 511223 Cow
Entrez Gene: 477292 Dog
Entrez Gene: 51028 Human
Entrez Gene: 70160 Mouse
Entrez Gene: 290851 Rat
Entrez Gene: 335810 Zebrafish
Omim: 610903 Human
SwissProt: A5PK00 Cow
SwissProt: Q86VN1 Human
SwissProt: Q91XD6 Mouse
SwissProt: P0C0A2 Rat
SwissProt: Q7ZVK4 Zebrafish
Unigene: 109520 Human
Unigene: 41453 Mouse
Unigene: 474298 Mouse
Unigene: 12707 Rat
Unigene: 21065 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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