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Rabbit Anti-EPCR/Gold Conjugated antibody (bs-9506R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-9506R-Gold
英文名稱 Rabbit Anti-EPCR/Gold Conjugated antibody
中文名稱 膠體金標記的內(nèi)皮細胞活化蛋白受體/CD201抗體
別    名 Activated protein C receptor; APC receptor; APCR; CCCA; CCD41; CD201 antigen; centrocyclin; Endothelial cell protein C receptor; MGC23024; PROCR; EPCR_HUMAN; CD201.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 心血管  細胞生物  免疫學(xué)  干細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPCR/CD201
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
EPCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. It is an N glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. It is expressed strongly in the endothelial cells of arteries and veins in heart and lung. It is overexpressed in several human non-Pgp multidrug resistant (MDR) tumor cell lines. Whether and how anti-coagulant and anti-inflammatory functions of EPCR facilitate oncogenesis and/or drug resistance is unclear.

Function:
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Post-translational modifications:
N-glycosylated.
A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.

Database links:

Entrez Gene: 10544 Human

Omim: 600646 Human

SwissProt: Q9UNN8 Human

Unigene: 647450 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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