| 產(chǎn)品編號(hào) |
bs-0815R-HRP |
| 英文名稱 |
Rabbit Anti-Megsin/HRP Conjugated antibody
|
| 中文名稱 |
辣根過(guò)氧化物酶標(biāo)記的絲氨酸蛋白酶抑制劑B7抗體 |
| 別 名 |
SER-PINB7; MEGSIN; Mesangium predominant gene megsin; MGC120014; MGC120015; Serpin B7; Serpin peptidase inhibitor clade B (ovalbumin) member 7; TP55; SPB7_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 激酶和磷酸酶 |
| 抗體來(lái)源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Rat,
(predicted: Human, Mouse, )
|
| 產(chǎn)品應(yīng)用 |
ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
42kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human Megsin (295-330aa) |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
Serpin B7 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in a search for agents responsible for thrombopoiesis, and maturation of megakaryocytes. SerpinB7 was identified as a protein that increased acetylcholine esterase stimulation from bone barrow progenitor cells, and injection of SerpinB7 in mice induced a 40% increase in platelets compared to controls. Shortly thereafter, in a search for kidney specific genes, SerpinB7 was described as a protein specific to mesangial cells, and was named megsin to indicate the tissue specificity of the protein.
Function:
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in mesangial cells.
Similarity:
Belongs to the serpin family. Ov-serpin subfamily.
Database links:
Entrez Gene: 8710 Human
Omim: 603357 Human
SwissProt: O75635 Human
Unigene: 138202 Human
Unigene: 742388 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
megsin是新近發(fā)現(xiàn)的蛋白質(zhì),屬于絲氨酸蛋白酶抑制劑（Serpin）超家族，特異表達(dá)于腎小球系膜細(xì)胞,其表達(dá)異常在腎臟疾病進(jìn)展中具有重要作用,megsin蛋白適量的表達(dá)，對(duì)維持人體正常的生理病理過(guò)程如凝血、纖維溶解、間質(zhì)代謝、發(fā)育、血壓、腫瘤和炎癥等是很重要的。在系膜細(xì)胞增生和系膜基質(zhì)增多明顯的IgA腎病腎小球中，megsin的表達(dá)顯著上調(diào)。
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