產(chǎn)品編號(hào) |
bs-1103R-BF594 |
英文名稱 |
Rabbit Anti-PD-L1/BF594 Conjugated antibody
|
中文名稱 |
BF594標(biāo)記的程序性死亡配體1抗體 |
別 名 |
CD274;
B7 H;
B7 H1;
B7 homolog 1;
B7-H1;
B7H;
B7H1;
CD 274;
CD274 antigen;
CD274 molecule;
MGC142294;
MGC142296;
OTTHUMP00000021029;
PD L1;
PD1L1_HUMAN;
PD1L1_Mouse;
PDCD1 ligand 1;
PDCD1L1;
PDCD1LG1;
PDL 1;
PDL1;
Programmed cell death 1 ligand 1;
Programmed death ligand 1;
RGD1566211. |
規(guī)格價(jià)格 |
100ul/2980元
購(gòu)買 大包裝/詢價(jià) |
說(shuō) 明 書 |
100ul
|
研究領(lǐng)域 |
腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 |
抗體來(lái)源 |
Rabbit |
克隆類型 |
Polyclonal |
交叉反應(yīng) |
Mouse,
(predicted: Rat, )
|
產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
分 子 量 |
32kDa |
性 狀 |
Lyophilized or Liquid |
濃 度 |
1mg/ml |
免 疫 原 |
KLH conjugated synthetic peptide derived from mouse B7-H1 |
亞 型 |
IgG |
純化方法 |
affinity purified by Protein A |
儲(chǔ) 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
產(chǎn)品介紹 |
background: Programmed cell death 1 ligand 1(Programmed death ligand 1;PD-L1; PDCD1 ligand 1; B7 homolog 1; B7-H1; CD274) involved in the costimulatory signal, essential for T lymphocyte proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibit T-cell proliferation and cytokine production.
Function: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Subunit: Interacts with PDCD1.
Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein.
Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Database links:
Entrez Gene: 29126 Human
Entrez Gene: 60533 Mouse
Entrez Gene: 499342 Rat
Omim: 605402 Human
SwissProt: Q9NZQ7 Human
SwissProt: Q9EP73 Mouse
Unigene: 521989 Human
Unigene: 245363 Mouse
Unigene: 228198 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
程序性死亡配體1(B7-H1)可以促進(jìn)上皮細(xì)胞的惡性轉(zhuǎn)化,保護(hù)表皮細(xì)胞免于失巢凋亡,在腫瘤的發(fā)生,進(jìn)展和轉(zhuǎn)歸中發(fā)揮重要作用.
目前對(duì)CD274信號(hào)通路的進(jìn)一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應(yīng)中T細(xì)胞介導(dǎo)的免疫應(yīng)答調(diào)控提供了新的途徑.B7-H1在癌癥、類風(fēng)濕、HIV感染等疾病中發(fā)現(xiàn)B7-H1有負(fù)調(diào)節(jié)作用。對(duì)B7-H1路徑進(jìn)行調(diào)控有助于自身免疫病及惡性腫瘤的治療。
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