| 產(chǎn)品編號 |
bs-1309R-BF594 |
| 英文名稱 |
Rabbit Anti-Syndecan-1/BF594 Conjugated antibody
|
| 中文名稱 |
BF594標(biāo)記的多配體蛋白聚糖1抗體 |
| 別 名 |
SDC1; SDC; SYND1; Syndecan I; SyndecanI; Syndecan-I; syndecan; Sdc1; Syndecan1; AA408134; AA409076; Sstn; syn-1; CD138; CD 138; CD-138; CD138 antigen; Heparan sulfate proteoglycan fibroblast growth factor receptor; SDC 1; Syndecan1 precursor; SDC1_HUMAN. |
| 規(guī)格價(jià)格 |
100ul/2980元
購買 大包裝/詢價(jià) |
| 說 明 書 |
100ul
|
| 研究領(lǐng)域 |
腫瘤 神經(jīng)生物學(xué) 細(xì)胞膜受體 細(xì)胞粘附分子 細(xì)胞表面分子 糖蛋白 上皮細(xì)胞 內(nèi)皮細(xì)胞 |
| 抗體來源 |
Rabbit |
| 克隆類型 |
Polyclonal |
| 交叉反應(yīng) |
Human, Rat, Cow,
(predicted: Mouse, Chicken, Dog, Pig, Horse, Rabbit, )
|
| 產(chǎn)品應(yīng)用 |
IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 |
34kDa |
| 性 狀 |
Lyophilized or Liquid |
| 濃 度 |
1mg/ml |
| 免 疫 原 |
KLH conjugated synthetic peptide derived from human CD138 |
| 亞 型 |
IgG |
| 純化方法 |
affinity purified by Protein A |
| 儲 存 液 |
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background:
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].
Function:
Cell surface proteoglycan that bears both heparin sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Subunit:
Interacts with CDCP1.
Subcellular Location:
Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.
Post-translational modifications:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Similarity:
Belongs to the syndecan proteoglycan family.
Database links:
Entrez Gene: 6382 Human
Entrez Gene: 20969 Mouse
Entrez Gene: 25216 Rat
Omim: 186355 Human
SwissProt: P18827 Human
SwissProt: P18828 Mouse
SwissProt: P26260 Rat
Unigene: 224607 Human
Unigene: 665958 Human
Unigene: 2580 Mouse
Unigene: 11176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Syndecan1(CD138)屬于Syndecans基因家族，該家族是一類細(xì)胞表面跨膜蛋白多糖 ,是膜表面粘附受體 ,參與細(xì)胞-細(xì)胞外基質(zhì)之間的粘附。
CD138表達(dá)于上皮細(xì)胞、胚胎間質(zhì)細(xì)胞、血管平滑肌細(xì)胞、內(nèi)皮細(xì)胞和神經(jīng)細(xì)胞基底膜。Syndecan-1與惡性腫瘤的發(fā)生發(fā)展、浸潤及轉(zhuǎn)移有關(guān)，著色于胞漿和胞膜.
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