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DSS1 Rabbit pAb (bs-14432R)  
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產品編號 bs-14432R
英文名稱 DSS1 Rabbit pAb
中文名稱 先天性裂手/裂足畸形相關蛋白DSS1抗體
別    名 26S proteasome complex subunit DSS1; Deleted in split hand/split foot 1; Deleted in Split-Hand/Split-Foot 1 region; ECD; SEM1; SHFD1; DSS1_HUMAN; SHFM1; SHSF1; PSMD15; Shfdg1; C7orf76; Split hand/foot deleted protein 1; Split hand/foot malformation(ectrodactyly) type 1; Split hand/foot malformation type 1 protein.  
研究領域 細胞生物  發(fā)育生物學  細胞周期蛋白  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Rabbit,Pig,Cow)
產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 8.3 kDa
檢測分子量
細胞定位 細胞核 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DSS1: 1-70/70 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]

Function:
The gene for DSS1 has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. DSS1 has been proposed to be a candidate for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.

Subunit:
Part of the 26S proteasome. Interacts with the C-terminal of BRCA2.

Tissue Specificity:
Expressed in limb bud, craniofacial primordial and skin.

Similarity:
Belongs to the DSS1/SEM1 family.

SWISS:
Q6ZVN7

Gene ID:
7979

Database links:

Entrez Gene: 7979 Human

Omim: 601285 Human

SwissProt: P60896 Human



產品圖片
Tissue/cell: human skin tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat s
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