| 產(chǎn)品編號(hào) | bs-2730R |
| 英文名稱(chēng) | ULBP3 Rabbit pAb |
| 中文名稱(chēng) | UL16結(jié)合蛋白3抗體 |
| 別 名 | ALCAN-gamma; N2DL-3; N2DL3; NKG2D ligand 3; NKG2D ligand 3 precursor; NKG2DL3; OTTHUMP00000017411; RAET1N; Retinoic acid early transcript 1N; UL16 binding protein 3; UL16-binding protein 3; N2DL3_HUMAN. |
| 研究領(lǐng)域 | 免疫學(xué) 自然殺傷細(xì)胞 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human) |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 25 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ULBP3: 101-200/244 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
ULBP3 is a human ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. ULBP3 has a lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Function: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. Subunit: Does not interact with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Similarity: Belongs to the MHC class I family. SWISS: Q9BZM4 Gene ID: 79465 Database links: Entrez Gene: 79465 Human Omim: 605699 Human SwissProt: Q9BZM4 Human Unigene: 326556 Human |
