| 產(chǎn)品編號(hào) | bs-2535R |
| 英文名稱 | TFPI Rabbit pAb |
| 中文名稱 | 組織因子途徑抑制劑抗體 |
| 別 名 | Tissue factor pathway inhibitor; Tissue factor pathway inhibitor-1; convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; TFI; TFPI 1; TFPI1; TFPI1_HUMAN. |
| 研究領(lǐng)域 | 心血管 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 32 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TFPI: 101-200/304 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
TFPI is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. TFPI is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Function: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Subcellular Location: Isoform Alpha: Secreted. Isoform Beta: Microsome membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Mostly in endothelial cells. Post-translational modifications: O-glycosylated. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. SWISS: P10646 Gene ID: 7035 Database links: Entrez Gene: 7035 Human Entrez Gene: 21788 Mouse Omim: 152310 Human SwissProt: P10646 Human SwissProt: O54819 Mouse Unigene: 516578 Human Unigene: 124316 Mouse Unigene: 447013 Mouse Unigene: 15795 Rat 組織因子途徑抑制因子(tissue factor pathway in hibitor, TFPI)是組織因子凝血途徑的主要抑制因子， 組織因子途徑抑制因子在諸如動(dòng)脈粥樣硬化，血管再狹窄，彌漫性血管內(nèi)凝血DIC等方面，有一定的研究?jī)r(jià)值。 |
| 產(chǎn)品圖片 |
Sample:
Heart (Mouse) Lysate at 40 ug
Lung (Rat) Lysate at 40 ug
Primary: Anti-TFPI (bs-2535R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 32 kD
Observed band size: 52 kD
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