| 產(chǎn)品編號 | bs-0039R |
| 英文名稱 | ADNP Rabbit pAb |
| 中文名稱 | 活性依賴的神經(jīng)保護(hù)肽抗體 |
| 別 名 | Activity dependent neuroprotective protein; Activity dependent neuroprotector; NAP; KIAA0784 |
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Specific References (1) | bs-0039R has been referenced in 1 publications.
[IF=2.59] Ma, Xian-Cang, et al. "Intranasal Delivery of Recombinant NT4-NAP/AAV Exerts Potential Antidepressant Effect." Neurochemical Research: 1-6. Human.
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| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse,Rat (predicted: Human,Cow,Chicken,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 114 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ADNP: 331-400/1102 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The activity dependent neuroprotective protein (ADNP) gene is frequently amplified in many neoplasias, including breast, bladder, ovarian, pancreatic, and colon cancers. ADNP mRNA is abundantly expressed in distinct normal tissues, and high expression levels were encountered in malignant cells. ADNP is implicated in maintaining cell survival, perhaps through modulation of p53. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor.
Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Subcellular Location: Nucleus (Potential). Tissue Specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues. Similarity: Contains 9 C2H2-type zinc fingers. Contains 1 homeobox DNA-binding domain. SWISS: Q9H2P0 Gene ID: 23394 Database links: Entrez Gene: 23394 Human Omim: 611386 Human SwissProt: Q9H2P0 Human Unigene: 570355 Human 是一個(gè)潛在的轉(zhuǎn)錄調(diào)節(jié)因子，參與正常細(xì)胞與腫瘤細(xì)胞的增殖調(diào)控。 廣泛分布于大腦、小腦等組織，在肺、腎、小腸以及睪丸等組織也有微弱的表達(dá)。對體外培養(yǎng)的glia缺失神經(jīng)元細(xì)胞有保護(hù)作用. |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ADNP) Polyclonal Antibody, Unconjugated (bs-0039R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ADNP) Polyclonal Antibody, Unconjugated (bs-0039R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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